Despite the availability of the smallpox vaccine, New York City still had large outbreaks of the disease, in part because of the arrival of infected immigrants. Located on the isolated southern tip of the island in an attempt to quarantine patients, the hospital contained a large charity ward in addition to private rooms on the upper floors. In 1875, the hospital closed and became a training center for nurses attached to City Hospital, later renamed Charity Hospital. Renwick designed the building in the Gothic Revival style, and in 1903-1905, two wings with the same architectural theme were added to the school, named the Home for the Nurses and the Maternity and Charity Hospital Training School, to accommodate the growing student base. In deference to the changing use of the island, in 1921 Blackwell’s Island was renamed Welfare Island, and many of the structures there fell into disrepair as they became obsolete. In the 1950s, both Charity Hospital and the nurses school were closed, and their operations moved to new buildings in Queens.